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Rhodes, Christopher
One or more keywords matched the following items that are connected to Rhodes, Christopher
Item TypeName
Concept Cell Fractionation
Concept Cell Membrane Permeability
Concept Cell Count
Concept Cell Differentiation
Concept Cell Nucleus
Concept Cell Membrane
Concept Cell Division
Concept Cell Separation
Concept Clone Cells
Concept Cell Adhesion
Concept Cell Cycle
Concept Cell Transformation, Neoplastic
Concept Epithelial Cells
Concept Leydig Cells
Concept HeLa Cells
Concept Receptors, Cell Surface
Concept Stem Cells
Concept CHO Cells
Concept Cell Culture Techniques
Concept Enteroendocrine Cells
Concept Tumor Cells, Cultured
Concept 3T3 Cells
Concept Cell Proliferation
Concept Calcium Signaling
Concept Jurkat Cells
Concept Intercellular Signaling Peptides and Proteins
Concept Primary Cell Culture
Concept Cell Cycle Proteins
Concept Caco-2 Cells
Concept Platelet Endothelial Cell Adhesion Molecule-1
Concept 3T3-L1 Cells
Concept Shc Signaling Adaptor Proteins
Concept HEK293 Cells
Concept Adaptor Proteins, Signal Transducing
Concept Insulin-Secreting Cells
Concept Cell Death
Concept Cell Dedifferentiation
Concept Cell Lineage
Concept MAP Kinase Signaling System
Concept Protein Sorting Signals
Concept Extracellular Signal-Regulated MAP Kinases
Concept Neural Stem Cells
Concept Hep G2 Cells
Concept Endothelial Cells
Concept Cell Line, Tumor
Concept Intracellular Signaling Peptides and Proteins
Concept Cell Size
Concept Cell Shape
Concept Suppressor of Cytokine Signaling Proteins
Concept Cell Line
Concept Cell Survival
Concept Cells, Cultured
Concept Signal Transduction
Academic Article Glucose-regulated translational control of proinsulin biosynthesis with that of the proinsulin endopeptidases PC2 and PC3 in the insulin-producing MIN6 cell line.
Academic Article A novel regulatory mechanism for trimeric GTP-binding proteins in the membrane and secretory granule fractions of human and rodent beta cells.
Academic Article Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells.
Academic Article Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins.
Academic Article Insulin-secreting non-islet cells are resistant to autoimmune destruction.
Academic Article The ratio of mouse insulin I:insulin II does not reflect that of the corresponding preproinsulin mRNAs.
Academic Article Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin.
Academic Article Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells).
Academic Article Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.
Academic Article A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth.
Academic Article Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).
Academic Article Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation.
Academic Article Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis.
Academic Article Glycerol-stimulated proinsulin biosynthesis in isolated pancreatic rat islets via adenoviral-induced expression of glycerol kinase is mediated via mitochondrial metabolism.
Academic Article Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis.
Academic Article Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation.
Academic Article A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties.
Academic Article Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells.
Academic Article Changes in cytoplasmic ATP concentration parallels changes in ATP-regulated K+-channel activity in insulin-secreting cells.
Academic Article Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation.
Academic Article Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling.
Academic Article Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes?
Academic Article Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation.
Academic Article A low-affinity Ca2+-dependent association of calmodulin with the Rab3A effector domain inversely correlates with insulin exocytosis.
Academic Article Gene and cell-replacement therapy in the treatment of type 1 diabetes: how high must the standards be set?
Academic Article Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats.
Academic Article Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis.
Academic Article Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1).
Academic Article Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells.
Academic Article Phosphoinositide 3 kinase mediates Toll-like receptor 4-induced activation of NF-kappa B in endothelial cells.
Academic Article Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide.
Academic Article Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin.
Academic Article Syncollin inhibits regulated corticotropin secretion from AtT-20 cells through a reduction in the secretory vesicle population.
Academic Article A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli.
Academic Article Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells.
Academic Article Fluorescent cargo proteins in pancreatic beta-cells: design determines secretion kinetics at exocytosis.
Academic Article Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells.
Academic Article Insulin receptor substrate 2 plays diverse cell-specific roles in the regulation of glucose transport.
Academic Article Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B.
Academic Article Type 2 diabetes-a matter of beta-cell life and death?
Academic Article Actin and non-muscle myosin II facilitate apical exocytosis of tear proteins in rabbit lacrimal acinar epithelial cells.
Academic Article 10th EASD/JDRF Oxford Workshop. What is a beta-cell and can we improve it?
Academic Article Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells.
Academic Article Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes.
Academic Article Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation.
Academic Article Impact of defined matrix interactions on insulin production by cultured human beta-cells: effect on insulin content, secretion, and gene transcription.
Academic Article Inositol (1,4,5)-trisphosphate dynamics and intracellular calcium oscillations in pancreatic beta-cells.
Academic Article Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons.
Academic Article Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?
Academic Article Decreasing IRS-2 expression in pancreatic beta-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression.
Academic Article Beta-cell regeneration: epithelial mesenchymal transition pre-EMTpted by lineage tracing?
Academic Article Proinsulin maturation, misfolding, and proteotoxicity.
Academic Article A cis-element in the 5' untranslated region of the preproinsulin mRNA (ppIGE) is required for glucose regulation of proinsulin translation.
Academic Article Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine beta-cells.
Academic Article Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell.
Academic Article Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells.
Academic Article Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element.
Academic Article Stimulation by ATP of proinsulin to insulin conversion in isolated rat pancreatic islet secretory granules. Association with the ATP-dependent proton pump.
Academic Article Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding.
Academic Article Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.
Academic Article Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death.
Academic Article The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion.
Academic Article Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level.
Academic Article Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 ß-cells and rat islets.
Academic Article The balance between proinsulin biosynthesis and insulin secretion: where can imbalance lead?
Academic Article Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance.
Academic Article Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3ß independent of JNK activation.
Academic Article Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells.
Academic Article Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway.
Academic Article AMP-activated protein kinase attenuates nitric oxide-induced beta-cell death.
Academic Article Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass.
Academic Article Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet.
Academic Article Formation of a human ß-cell population within pancreatic islets is set early in life.
Academic Article Degradation of islet amyloid polypeptide by neprilysin.
Academic Article Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases.
Academic Article How does type 1 diabetes develop?: the notion of homicide or ß-cell suicide revisited.
Academic Article FoxO feedback control of basal IRS-2 expression in pancreatic ß-cells is distinct from that in hepatocytes.
Academic Article A Kex2-related endopeptidase activity present in rat liver specifically processes the insulin proreceptor.
Academic Article What beta-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism.
Academic Article PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells.
Academic Article Mechanism of action of glucagon-like peptide-2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts.
Academic Article Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet ß-cells.
Academic Article The intracellular handling of insulin-related peptides in isolated pancreatic islets. Evidence for differential rates of degradation of insulin and C-peptide.
Academic Article Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1.
Academic Article Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation.
Academic Article Molecular insights into insulin action and secretion.
Academic Article Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).
Academic Article Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis.
Academic Article IRS-3 inhibits IRS-2-mediated signaling in pancreatic beta-cells.
Academic Article Diazoxide attenuates glucose-induced defects in first-phase insulin release and pulsatile insulin secretion in human islets.
Academic Article Glucagon-like peptide-1 prevents beta cell glucolipotoxicity.
Academic Article Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion.
Academic Article The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species.
Academic Article Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic beta-cells.
Academic Article Effect of interferon and double-stranded RNA on B-cell function in mouse islets of Langerhans.
Academic Article Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve.
Academic Article Glycogen synthase kinase 3 beta mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1.
Academic Article Effects of glucose and D-3-hydroxybutyrate on human pancreatic islet cell function.
Academic Article Rab3A effector domain peptides induce insulin exocytosis via a specific interaction with a cytosolic protein doublet.
Academic Article Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways.
Academic Article IGF-I and GH post-receptor signaling mechanisms for pancreatic beta-cell replication.
Academic Article Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells.
Academic Article Intracellular signalling. Key enzyme in leptin-induced anorexia.
Academic Article A potential role for hypothalamomedullary POMC projections in leptin-induced suppression of food intake.
Academic Article ß1 integrin is a crucial regulator of pancreatic ß-cell expansion.
Academic Article Islet autoantigens: structure, function, localization, and regulation.
Academic Article Direct autocrine action of insulin on ß-cells: does it make physiological sense?
Academic Article Characterization of the promoter for the rat and human link protein gene.
Academic Article Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neurons.
Academic Article ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.
Academic Article ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.
Academic Article Developmental expression of the translocator protein 18 kDa (TSPO) in testicular germ cells.
Academic Article a1-A680T variant in GUCY1A3 as a candidate conferring protection from pulmonary hypertension among Kyrgyz highlanders.
Academic Article Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension.
Academic Article Monomethylated-adenines potentiate glucose-induced insulin production and secretion via inhibition of phosphodiesterase activity in rat pancreatic islets.
Academic Article Pancreatic ß-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function.
Academic Article RNA Sequencing Analysis Detection of a Novel Pathway of Endothelial Dysfunction in Pulmonary Arterial Hypertension.
Academic Article SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed ß cells.
Academic Article In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and Its Target Slug.
Academic Article Free Fatty Acid-Induced Inhibition of Glucose and Insulin-Like Growth Factor I-Induced Deoxyribonucleic Acid Synthesis in the Pancreatic ß-Cell Line INS-1* * This work was supported by grants from the NIH (GK-55267), the Juvenile Diabetes Foundation International, the German Research Society, and BetaGene, Inc.
Academic Article Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats.
Academic Article Codependence of Bone Morphogenetic Protein Receptor 2 and Transforming Growth Factor-ß in Elastic Fiber Assembly and Its Perturbation in Pulmonary Arterial Hypertension.
Academic Article Ca(2+)-regulated serine protease associated with the nuclear scaffold.
Academic Article Dominant-negative PKC-epsilon impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini.
Academic Article BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFß-TAK1-MAPK pathways in PAH.
Academic Article Leptin action in the forebrain regulates the hindbrain response to satiety signals.
Academic Article An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28.
Academic Article Red cell distribution width outperforms other potential circulating biomarkers in predicting survival in idiopathic pulmonary arterial hypertension.
Academic Article Spatial organization of EphA2 at the cell-cell interface modulates trans-endocytosis of ephrinA1.
Academic Article Transepithelial transport of poly(amidoamine) dendrimers across Caco-2 cell monolayers.
Academic Article Iron deficiency and raised hepcidin in idiopathic pulmonary arterial hypertension: clinical prevalence, outcomes, and mechanistic insights.
Academic Article Therapeutic targets in pulmonary arterial hypertension.
Academic Article Subcellular resolution mapping of endogenous cytokine secretion by nano-plasmonic-resonator sensor array.
Academic Article Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata.
Academic Article Free radicals, metals and antioxidants in oxidative stress-induced cancer.
Academic Article Role of oxygen radicals in DNA damage and cancer incidence.
Academic Article Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity.
Academic Article Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1.
Academic Article Identification of the Novel Tooth-Specific Transcription Factor AmeloD.
Academic Article ß-Cell Control of Insulin Production During Starvation-Refeeding in Male Rats.
Academic Article PACE4 is a member of the mammalian propeptidase family that has overlapping but not identical substrate specificity to PACE.
Academic Article Plasmonic nanoparticles and solar cells.
Academic Article Redox- and non-redox-metal-induced formation of free radicals and their role in human disease.
Academic Article The dynamic plasticity of insulin production in ß-cells.
Academic Article The enzymology of proinsulin conversion.
Academic Article miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia.
Academic Article Association of synovial inflammation and inflammatory mediators with glenohumeral rotator cuff pathology.
Academic Article Identification of rare sequence variation underlying heritable pulmonary arterial hypertension.
Academic Article Pancreatic ß-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes.
Academic Article Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.
Academic Article Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production.
Academic Article Proteomic Analysis of Restored Insulin Production and Trafficking in Obese Diabetic Mouse Pancreatic Islets Following Euglycemia.
Academic Article Mendelian randomisation analysis of red cell distribution width in pulmonary arterial hypertension.
Academic Article Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding.
Academic Article Targeting Vessel Formation in Pulmonary Arterial Hypertension: Is the Endostatin-Id1-Thrombospondin 1 Pathway a New Hope?
Academic Article Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension.
Academic Article The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti.
Academic Article Characterization of Signaling Pathways Associated with Pancreatic ß-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in db/db Mice.
Academic Article A fluorescent timer reporter enables sorting of insulin secretory granules by age.
Academic Article Characterization of Signaling Pathways Associated with Pancreatic ß-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in db/db Mice.
Academic Article A genetic map of the mouse dorsal vagal complex and its role in obesity.
Academic Article A diagnostic miRNA signature for pulmonary arterial hypertension using a consensus machine learning approach.
Academic Article Severe Pulmonary Arterial Hypertension Is Characterized by Increased Neutrophil Elastase and Relative Elafin Deficiency.
Academic Article Peptide-YY3-36/glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic ß-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries.
Academic Article Transcriptional heterogeneity of ventricular zone cells in the ganglionic eminences of the mouse forebrain.
Academic Article Calcineurin/NFATc2 and PI3K/AKT signaling maintains ß-cell identity and function during metabolic and inflammatory stress.
Academic Article An organ-on-chip model of pulmonary arterial hypertension identifies a BMPR2-SOX17-prostacyclin signalling axis.
Academic Article PTPN1 Deficiency Modulates BMPR2 Signaling and Induces Endothelial Dysfunction in Pulmonary Arterial Hypertension.
Concept Cell Plasticity
Concept Suppressor of Cytokine Signaling 3 Protein
Concept Sf9 Cells
Grant Mitogenic Signal Transduction in Pancreatic Beta-Cells
Grant Metabolic Control of Insulin Exocytosis
Grant Central Control of Pancreatic Islet Function
Grant Western Region Islet Study Group
Grant An Interdisciplinary Molecular Metabolism Training Program
Grant Metabolic Control of Proinsulin Biosynthesis Translation
Grant Metabolic Control of Proinsulin Biosynthesis Translation
Academic Article Serum and Pulmonary Expression Profiles of the Activin Signaling System in Pulmonary Arterial Hypertension.
Academic Article SOX17 Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension.
Academic Article Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension.
Academic Article Multi-biobank summary data Mendelian randomisation does not support a causal effect of IL-6 signalling on risk of pulmonary arterial hypertension.
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